Trk signaling as a backprop mechanism?

From this week’s Nature, the Poo lab shows how BDNF-induced plasticity in the optic tectum can lead to “back-propogated” changes in AMPA receptor density one synapse back in retinal ganglion cells. Click below for the full abstract
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Brain's genes begin to deteriorate at 40!

From the WSJ:

HEALTH
As Early as Age 40, Genes in the Brain Begin to Deteriorate
By LAURA JOHANNES, Staff Reporter of THE WALL STREET JOURNAL
June 10, 2004; Page D1

Harvard University researchers found that 20 genes critical for
learning and memory begin to decline in function as early as age 40,
pointing the way for further research aimed at tackling the mental
infirmities that come with growing old.
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