Rimonabant (aka SR141716), a CB1 receptor antagonist, is being investigated as a diet drug. This is disturbing to me because of the significant acute effects of cannibinoids on cognitive function.
Note also that the function of endocannabinoids is a mystery but it is a hot area of research right now and they have been implicated in, amongst other things, plasticity. I am already aware of at least one study implicating Rimonabant in changes in cognitive function (the study; press release). (in addition to emotional function; the drug trials revealed an increased incidence of depression amongst Rimonabant users as compared to placebo).
I’m not saying that this is definitely not a good diet drug. The cognitive changes could be minor, or they be beneficial, or they could be outweighed by the weight loss effects. But the cognitive effects might also be subtle and hard to detect. I just hope the patients understand that drug affects the brain in unknown and possibly significant ways. I feel that people should take the decision to chronically consume this drug as seriously as they would consider chronically consuming marijuana (a CB1 agonist).