The company says the freezing effect comes from two ingredients: gamma aminobutyric acid, a substance found in the human nervous system that can block signals between nerves and muscles, and gynostemma pentaphyllum extract, derived from an herb used in traditional Chinese medicine. The company contends that gamma aminobutyric acid, a molecule that stays on the skin’s surface, activates smaller gynostemma molecules and sends them through the skin, where they signal muscles to relax, according to Gene Beilis, a pharmacist who is the vice president for product development at Freeze 24/7.
But the company has no scientific evidence to back up its claim that its products actually affect facial muscles.
And further down:
Mr. Beilis agreed that gamma aminobutyric acid is a powdery substance that coagulates when it dries, gripping the skin in place. Another ingredient in the product, eugenol, a clove derivative used in dentistry as an analgesic, “gives you a cool, numbing, tingling sensation,” he said.