Deisseroth on new step ChR2

Nature methods has a small piece interviewing Karl Deisseroth on properties of the new step ChR2.

Some shortcomings of step ChR2 and future research directions:

Deisseroth expects ongoing efforts to improve key features of these channels. “One disadvantage is that some of the mutants have reduced current compared to wild type, so multiple mutations may help to bring those current levels back up to wild-type levels,” he says. Projects designed to improve membrane targeting and to apply a composite of opsins, including the red light–responsive channelrhodopsin from Volvox carteri, are also in the works in his laboratory.

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