Expression data is now available for over 60K gene probes over the entire human brain. Click here to access this monster data set!
More info after the jump.
I am writing to let you know that we have just launched our first data set mapping gene expression across an adult human brain. As with all Allen Institute Atlases, the data is freely available at www.brain-map.org For this first release, we have included:
· Spatially mapped microarray data for over 700 distinct anatomic locations throughout the brain and containing information for over 62,000 gene probes with 93% of known genes represented by at least 2 probes
· A hierarchical anatomic naming system (ontology) integrating leading schemes for different brain regions
· Searches by anatomic region, probe, or gene, as well as queries for comparing expression among pre-selected structure sets
· Expert neuroanatomic annotation of brain structures and delineation of areas sampled for microarray analysis
· An in situ hybridization study from a separate adult human brain that characterizes 55 genes in subcortical regions extending from the front of the caudate through posterior substantia nigra, and a smaller set of 10 genes through the hypothalamus. The 55-gene set focuses on the glutamatergic and GABAergic systems.
We hope that you might find these to be valuable resources, and will be continuing to add data from additional brains (8-10 in total) and improving our tools for analysis over the next few years. As always, we appreciate your feedback, both good and bad. If the tools and data have helped in some meaningful way, please let us know…though we can track basic usage of the data through web hits, your personal stories really help justify the continued support of the existing resources and our ability to create more.
Allan R. Jones, PhD
Chief Executive Officer
Allen Institute for Brain Science
551 N. 34th St.
Seattle WA 98103