Limited mediated telepathy

A rat was implanted with a 32-unit microelectrode cortical array in either M1 or S1. The rat was then trained to choose between two alternatives based on external stimuli.

Meanwhile, another rat was implanted with 6 stimulating electrodes in the same area as the first rat. It was trained to choose between the same two alternatives based on a stimulation pattern conveyed via the electrodes.

Then the signals recorded from the first rat’s brain were processed ald sent into the second rat’s brain. Both rats were trained together and both were rewarded when both made the right choice. The second rat learned to make the same choice as the first rat 60% of the time.

Miguel Pais-Vieira, Mikhail Lebedev, Carolina Kunicki, Jing Wang, Miguel A. L. Nicolelis. A Brain-to-Brain Interface for Real-Time Sharing of Sensorimotor Information. Scientific Reports 3, Article number: 1319. Received 20 December 2012.

A subpopulation of nociceptors specifically linked to itch

Excerpt from the abstract: “We genetically labeled and manipulated MrgprA3+ neurons in the dorsal root ganglion (DRG) and found that they exclusively innervated the epidermis of the skin and responded to multiple pruritogens. Ablation of MrgprA3+ neurons led to substantial reductions in scratching evoked by multiple pruritogens and occurring spontaneously under chronic itch conditions, whereas pain sensitivity remained intact.”

Mobile phone increases brain glucose metabolism near phone antenna

This study claims that glucose metabolism in the brain goes up near a cellphone antenna. At first blush this may appear to conflict with other studies that claim that cellphones don’t cause cancer, but this can be resolved by supposing that cell phones don’t cause cancer, but affect the brain in other ways. As Volkow notes at the end of the Nytimes article, this may lead to the discovery of a mechanism for brain stimulation. Right now they don’t know what the mechanism is by which the electromagnetic field is causing the glucose metabolism. If neuronal firing is being altered, and if the bandwidth turns out to be sufficiently high (i.e. if the stimulation can be made sufficiently precise), this could eventually lead to a wireless brain-machine interface/neural prosthetic.

PET scans showing effect

Nora D. Volkow, Dardo Tomasi, Gene-Jack Wang, Paul Vaska, Joanna S. Fowler, Frank Telang, Dave Alexoff, Jean Logan, Christopher Wong. Effects of Cell Phone Radiofrequency Signal Exposure on Brain Glucose Metabolism. JAMA. 2011;305(8):808-813.

Summary in NYtimes: Cellphone Use Tied to Brain Changes

Transcranial Pulsed Ultrasound Stimulates Intact Brain Circuits

Yusuf Tufail, Alexei Matyushov, Nathan Baldwin, Monica L. Tauchmann, Joseph Georges, Anna Yoshihiro, Stephen I. Helms Tillery, William J. Tyler. Transcranial Pulsed Ultrasound Stimulates Intact Brain Circuits. Neuron, Volume 66, Issue 5, 681-694, 10 June 2010.

In motor cortex, ultrasound-stimulated neuronal activity was sufficient to evoke motor behaviors. Deeper in subcortical circuits, we used targeted transcranial ultrasound to stimulate neuronal activity and synchronous oscillations in the intact hippocampus. We found that ultrasound triggers TTX-sensitive neuronal activity in the absence of a rise in brain temperature (<0.01°C). Here, we also report that transcranial pulsed ultrasound for intact brain circuit stimulation has a lateral spatial resolution of approximately 2 mm and does not require exogenous factors or surgical invasion.

Neural Interfaces workshop, conference, June 20-23 (student status letter due tomorrow)

1. Beyond Brain Machine Interface: From Senses to Cognition
Co-sponsored by IEEE Engineering in Medicine and Biology Society and Army Research Office
June 20, 2010, Long Beach, CA
Travel fellowships, poster abstracts, and registration:

2. 39th Neural Interfaces Conference
Co-sponsored by NIH Deep Brain Stimulation Consortium
June 21-23, 2010, Long Beach, CA
Free registration for students (Faculty Advisor letter due May 21)
Program, registration, and further information:
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